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Andy Morgan's avatar

I appreciate that this comes from a good place, but it seems like a strawman argument and a bit misleading.

For one, EA hasn't been around for 35 years, making your title quite misleading, and you when you do acknowledge the work that EA organisations have done to accelerate vaccine development and approval its tucked in a small footnote at the end rather than in the body of the article.

This argument, that systems work is important, also isn't new to the community and has been engaged on extensively. But the arguments, both for and against, aren't included in this article whatsoever.

To be honest, this feels like you're both aiming for engagement and pushing abundance as a new cause area (all the while bundling vaccine approval advocacy with housing reform in the most wealthy country in the world), rather than providing good-faith feedback to the EA community.

Jacob Van Oorschot's avatar

The article linked to support the claim there has "been a malaria vaccine since the 1980s" says that the protein used by the current malaria vaccine was identified in 1980 and had its gene sequenced in 1984. The trial showing the efficacy of an actual vaccine based on that protein (albeit only 34% efficacy, which is abysmal) took place in 1998 and was published in 2001. We accept the low efficacy of RTS,S now because it's all we've got after decades of trying and developing vaccines against parasites is hard, but I would image for a long time there was hope that a better vaccine could be developed. RTS,S also requires 4 does and needs a cold chain which kind of sucks if you want to roll it out across malaria-endemic regions. Bednets are a more straightforward solution to implement. Obviously, in an ideal world, both are provided to as many people as possible but everything has an opportunity cost.

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